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SASInstitute A00-282 Exam Syllabus Topics:

SectionWeightObjectives
Manage Clinical Trials Data5%- Access and explore clinical datasets
- Use SQL and dictionary tables
- Clean, merge, and subset data
Transform or Summarize Clinical Trials Data15%- Aggregation and transposition
- Data step manipulation
- Derive variables and study days
Clinical Trials Data Structures10%- Define.xml and dataset specifications
- CDISC standards: SDTM, ADaM
- Clinical domain structures
Validate Clinical Trial Data Reporting20%- Programming validation techniques
- Use PROC COMPARE and log review
- Validation principles
Macro Programming for Clinical Trials15%- Debugging macros
- Create and call macros
- Macro variables and parameters
Report Clinical Trials Results10%- PROC REPORT and PROC PRINT
- Produce tables, listings, and figures
Clinical Trials Process5%- Clinical trial lifecycle and protocol
- Derive programming requirements from protocol and CRF
Regulatory Submissions5%- ICH and FDA guidelines
- Compliance for clinical data reporting
Apply Statistical Procedures for Clinical Trials15%- PROC MEANS, FREQ, TABULATE
- Basic statistical analysis for clinical data

SASInstitute Clinical Trials Programming Using SAS 9.4 Sample Questions:

Question 1

Vital Signs are a component of which SDTM class?

A. Events
B. Special Purpose
C. Findings
D. Interventions


Question 2

Which program will report all created output objects in the log?

A. proc ttest data=WORK.DATA1 ods=trace; class TREAT; var RESULTS; run;
B. ods trace log; proc ttest data=WORK.DATA1; class TREAT; var RESULTS; run;
C. ods trace=log; proc ttest data=WORK.DATA1; class TREAT; var RESULTS; run;
D. ods trace on; proc ttest data=WORK.DATA1; class TREAT; var RESULTS; run;


Question 3

This question will ask you to provide a line of missing code.
Given the following log entry:

Which line of code would produce the merge issue notes in the log?

A. %if indm ne indisp %then %put 'MERGE ISSUE: ' subjid= indm= indisp=;
B. if indm ne indisp then put 'MERGE ISSUE: ' subjid= indm= indisp=;
C. if indm ne indisp then output 'MERGE ISSUE: ' subjid= indm= indisp=;
D. if indm ne indisp then put 'MERGE ISSUE: ' _all_;


Question 4

Which two variables are required in BDS ADaM data sets?
(Choose two.)

A. STUDYID
B. ASEQ
C. AVAL
D. PARAM


Question 5

A Statistical Analysis Plan (SAP) defines the selection process for baseline records. This instructs the programmer to choose the last non-missing analyte value prior to first study drug administration (date/time).
The DEMO data set contains the date/time of first study drug administration for subject:

What will be the resulting baseline values, as selected per the SAP instructions?

A. Option D
B. Option B
C. Option C
D. Option A


Solutions:

Question 1
Answer: C
Question 2
Answer: D
Question 3
Answer: B
Question 4
Answer: A,D
Question 5
Answer: A

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